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squamous cell carcinoma in situ (Bowen's disease)
A solitary slowly enlarging erythematous plaque with a sharp border & little infiltration.
Etiology:
1) ultraviolet radiation
2) ingestion of inorganic trivalent arsenic
Pathology:
- anaplastic in situ squamous cell carcinoma skin
Clinical manifestations:
1) solitary slowly enlarging erythematous plaque with a sharp border & little infiltration
2) generally slight scaling & some crusting
3) no fine thread-like border as occurs in superficial basal cell carcinoma
4) circumscribed erythematous or pigmented patches with keratotic surface [3]
Management:
1) cryotherapy with liquid nitrogen
2) topical 5-fluorouracil
3) topical imiquimod [2]
Interactions
disease interactions
Related
superficial basal cell carcinoma
General
squamous cell carcinoma of the skin (SCCS)
References
- Color Atlas and Synopsis of Clinical Dermatology, Common
and Serious Diseases, 3rd ed, Fitzpatrick et al, McGraw Hill, NY,
1997, pg 223
- Morton CA, Birnie AJ, Eedy DJ.
British Association of Dermatologists' guidelines for the
management of squamous cell carcinoma in situ (Bowen's disease)
2014.
Br J Dermatol. 2014 Feb;170(2):245-60
PMID: 24313974
- Medical Knowledge Self Assessment Program (MKSAP) 19
Board Basics. An Enhancement to MKSAP19.
American College of Physicians, Philadelphia 2022